The contribution of platelet glycoproteins (GPIa C807T and GPIba C-5T) and cyclooxygenase 2 (COX-2G-765C) polymorphisms to platelet response in patients treated with aspirin |
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Authors: | Sayer I Al-Azzam Karem H Alzoubi Omar F Khabour Deniz Tawalbeh Ola Al-Azzeh |
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Institution: | 1. Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan;2. Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan |
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Abstract: | ObjectiveAspirin is an antiplatelet agent commonly used in treatment of patients with high risk to develop stroke and myocardial infarction. However, inter-individual variability regarding the inhibition of platelet function by aspirin is well documented. In this study, the correlation between platelet glycoproteins (GPIa C807T and GPIba C-5T) and cyclooxygenase 2 (COX-2G-765C) polymorphisms and antiplatelet response in patients treated with aspirin was investigated.MethodsJordanian adult patients (n = 584) who are taking aspirin as an antiplatelet agent participated in the study. Platelet aggregation response was measured using Multiplate Analyzer® system. Polymerase chain reaction–restriction fragment length polymorphism assay (PCR–RFLP) was used for genotyping of the examined polymorphisms.ResultsAspirin resistance was found in 15.8% of patients. Response to aspirin was significantly associated with GPIba C-5T polymorphism (P < 0.05). However, the GPIa C807T and COX-2G-765C polymorphisms were not related to aspirin resistance (P > 0.05).ConclusionA considerable fraction of the Jordanian population is resistant to the antiplatelet effect of aspirin, which might be related to GPIba C-5T polymorphism. |
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Keywords: | GPIa Platelet glycoprotein Ia GPIbα Platelet glycoprotein Ibα COX 2 Cyclooxygenase 2 PCR&ndash RFLP Polymerase chain reaction restriction fragment length polymorphism COX Cyclooxygenases TXA2 Thromboxane A2 VWF Von Willebrand factor TIA Transient ischemic attack MI Myocardial infarction NSIADs Nonsteroidal antiinflammatory drugs GPIIb/IIIa Platelet glycoprotein IIb/IIIa HbA1C Glycosylated hemoglobin BMI Body mass index SPSS Statistical Package for the Social Sciences SNPs single nucleotide polymorphisms |
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