Evaluation of hypermethylation and expression pattern of GMR2, GMR5, GMR8, and GRIA3 in patients with schizophrenia |
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| Authors: | Dor Mohammad Kordi-Tamandani Nahid DahmardehAdam Torkamanzehi |
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| Institution: | Department of Biology, University of Sistan and Baluchestan, Zahedan, Iran |
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| Abstract: | Emerging evidence suggests a role of dysfunction of glutamatergic neurotransmission and its receptors in the pathophysiology of schizophrenia (SCZ). This study evaluated whether the promoter hypermethylation and RNA expression pattern of GMR2 (glutamate metabotropic receptor), GMR5, GMR8, and GRIA3 (glutamate receptor, ionotropic alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) are associated with the risk of schizophrenia between schizophrenia patients and healthy controls. |
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| Keywords: | GMR2 Glutamate metabotropic receptor GMR5 Glutamate metabotropic receptor 5 GMR8 Glutamate metabotropic receptor 8 GRIA3 Glutamate receptor ionotropic alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid SCZ Schizophrenia MS-PCR Methylation-specific polymerase chain reaction mGluRs Metabotropic glutamate receptors iGluRs Ionotropic receptors NMDA N-methyl-d-aspartate EDTA Ethylenediaminetetraacetic acid M Methylation U Unmethylation OR Odds ratio CI Confidence interval Ref Reference |
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