The interleukin-4 − 589C/T polymorphism and the risk of asthma: A meta-analysis including 7345 cases and 7819 controls |
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Authors: | Wei Nie Zhaoqin Zhu Xin Pan Qingyu Xiu |
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Institution: | 1. Department of Respiratory Disease, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China;2. Pathogen Diagnosis and Biosafety Department, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China;3. Department of Medical Section, Zhenjiang Emergency Center, Jiangsu 212003, China |
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Abstract: | BackgroundA number of studies assessed the association of − 589C/T polymorphism in the promoter region of interleukin-4 (IL-4) with asthma in different populations. However, the results were contradictory. A meta-analysis was conducted to investigate the association between polymorphism in the IL-4 and asthma susceptibility.MethodsDatabases including Pubmed, EMBASE, Wanfang Database, China National Knowledge Infrastructure (CNKI) and Weipu Database were searched to find relevant studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations.ResultsThirty-four studies involving 7345 cases and 7819 controls were included. Overall, significant association between − 589C/T polymorphism and asthma was observed for TT + CT vs. CC (OR = 1.26; 95% CI 1.12–1.42; P = 0.0001; I2 = 26%). In the subgroup analysis by ethnicity, significant associations were found among Asians (OR = 1.36; 95% CI 1.07–1.73; P = 0.01; I2 = 0%) and Caucasians (OR = 1.30; 95% CI 1.09–1.54; P = 0.004; I2 = 53%) but not among African Americans (OR = 1.20; 95% CI 0.72–2.00; P = 0.48; I2 = 48%). In the subgroup analysis by atopic status, no significant association was found among atopic asthma patients (OR = 1.20; 95% CI 0.92–1.34; P = 0.27; I2 = 6%) and non-atopic asthma patients (OR = 0.97; 95% CI 0.73–1.28; P = 0.81; I2 = 0%).ConclusionsThis meta-analysis suggested that the IL-4 − 589C/T polymorphism was a risk factor of asthma. |
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Keywords: | AHR airway hyperresponsiveness IL-4 interleukin-4 OR odds ratio CI confidence interval HWE Hardy&ndash Weinberg equilibrium SNP single nucleotide polymorphism |
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