Association of the I148M/PNPLA3 variant with elevated alanine transaminase levels in normal-weight and overweight/obese Mexican children |
| |
| Authors: | Elena Larrieta-Carrasco,Paola Leó n-Mimila,Teresa Villarreal-Molina,Hugo Villamil-Ramí rez,Sandra Romero-Hidalgo,Leonor Jacobo-Albavera,Roxana Gutié rrez-Vidal,Blanca E. Ló pez-Contreras,Luz E. Guillé n-Pineda,Fausto Sá nchez-Muñ oz,Rafael Bojalil,Ana M. Mejí a-Domí nguez,Nahú m Mé ndez-Sá nchez,Aaron Domí nguez-Ló pez,Carlos A. Aguilar-Salinas,Samuel Canizales-Quinteros |
| |
| Affiliation: | 1. Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán” (INCMNSZ), Mexico City, Mexico;2. Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM-Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico;3. Laboratorio de Genómica de Enfermedades Cardiovasculares, INMEGEN, Mexico City, Mexico;4. Laboratorio de Genómica Computacional, INMEGEN, Mexico City, Mexico;5. Departamento de Endocrinología y Metabolismo, INCMNSZ, Mexico City, Mexico;6. Departamento de Inmunología, Instituto Nacional de Cardiología “Ignacio Chávez” (INCICh), Mexico City, Mexico;g Banco de Sangre, INCICh, Mexico City, Mexico;h Unidad de Investigación del Hígado, Fundación Médica Sur, Mexico City, Mexico;i Departamento de Gastroenterología, INCMNSZ, Mexico City, Mexico |
| |
| Abstract: | Background and aimsNon-alcoholic fatty liver disease (NAFLD) and elevated alanine transaminase (ALT) levels are common in obese Hispanic adults and children. Recently, a PNPLA3 gene variant (I148M) was strongly associated with NAFLD and higher ALT levels in obese adults, including Hispanics. The aims of this study were to estimate the frequency of elevated ALT levels, and to address the influence of obesity and PNPLA3/I148M on ALT levels in a general population sample of Mexican school-aged children.MethodsA total of 1037 non-related Mexican children aged 6 to 12 years were genotyped for the I148M variant. Anthropometric, clinical and metabolic parameters were collected from all participants.ResultsElevated ALT levels (> 35 U/L) were more frequent in obese (26.9%) and overweight (9.3%) than in normal weight children (2.2%). The M148M genotype was significantly associated with elevated ALT levels in this population (OR = 3.7, 95% CI 2.3–5.9; P = 3.7 × 10− 8), and children carrying the M148M genotype showed significantly lower HDL cholesterol levels and BMI z-core (P = 0.036 and 0.015, respectively). On stratifying by BMI percentile, this genotype conferred a much greater risk of elevated ALT levels in normal weight (OR = 19.9, 95% CI 2.5–157.7; P = 0.005) than overweight and obese children (OR = 3.4, 95% CI 1.3–8.9; P = 0.014 and OR = 3.1, 95% CI 1.7–5.5; P = 1.4 x10− 4, respectively).ConclusionsThe I148M PNPLA3 variant is strongly associated with elevated ALT levels in normal weight and overweight/obese Mexican children. Thus, the M148M genotype may be considered as an important risk factor for liver damage in this population. |
| |
| Keywords: | NAFLD, non-alcoholic fatty liver disease ALT, alanine transaminase AST, aspartate transaminases PNPLA3, patatin-like phospholipase domain-contain 3 BMI, body mass index HOMA-IR, homeostasis model assessment for insulin resistance HDL-C, high-density lipoprotein cholesterol OR, odds ratio |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
