Update meta-analysis on MMP-7 − 181A>G polymorphism and cancer risk: Evidence from 25 studies |
| |
Authors: | Xueling Yang Ya Liu Yufeng Yang Bo Li |
| |
Institution: | 1. Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, Jilin, China;2. School of Mathematics, Jilin University, Jilin, China;3. Department of Epidemiology and Statistics, School of Public Health, Jilin University, Jilin, China |
| |
Abstract: | BackgroundThe matrix metalloproteinase (MMP) can degrade various components of the extracellular matrix and its functional genetic polymorphism may be associated with cancer development. The common MMP-7 (− 181A>G) genetic polymorphism has been reported to be functional and may contribute to genetic susceptibility to cancers. However, the association between MMP-7 (− 181A>G) and cancer risk remains inconclusive.MethodsTo better understand the role of MMP-7 (− 181A>G) polymorphism in global cancer, we conducted this comprehensive meta-analysis encompassing 6392 cases and 7665 controls.ResultsOverall, the MMP-7 (− 181A>G) polymorphism was associated with higher cancer risk. In the stratified analyses, significant associations were found between the MMP-7 (− 181A>G) polymorphism and gastric cancer, ESCC and gynecologic cancer. We also observed that the GG genotype might modulate colorectal cancer risk comparing with the AA genotype (OR = 1.311.02–1.69]). Moreover, a significantly increased cancer risk was found among Asian populations. When stratified by study design, significantly elevated susceptibility to cancer was found among population-based studies.ConclusionsThese findings suggested that the MMP-7 (− 181A>G) genetic polymorphism may contribute to the susceptibility of cancers, especially among Asian population. |
| |
Keywords: | MMP matrix metalloproteinase ESCC esophageal squamous cell carcinoma PCR&ndash RFLP polymerase chain reaction&ndash restriction fragment length polymorphism HWE Hardy&ndash Weinberg equilibrium TNF-α tumor necrosis factor α |
本文献已被 ScienceDirect 等数据库收录! |
|