| MiRNA介导circRNA调控肿瘤的发展 |
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| 引用本文： | 李乐璇,张苗,邹军.MiRNA介导circRNA调控肿瘤的发展[J].中国细胞生物学学报,2021(1). |
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| 作者姓名： | 李乐璇 张苗 邹军 |
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| 作者单位： | 上海体育学院运动科学学院 |
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| 基金项目： | 国家自然科学基金(批准号:81871835);上海市人类运动能力开发与保障重点实验室(上海体育学院)(批准号:11DZ2261100)资助的课题。 |
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| 摘 要： | CircRNA(circular RNA)是一种具有特殊环形结构的ncRNA(non-coding RNA),并具有多种生物学功能。随着研究的深入,发现circRNA能够通过海绵吸附抑制miRNA(micro RNA)的表达,进而调控各系统肿瘤的发展。此外,一种circRNA也可参与调控一种或多种miRNA的表达,这一发现有助于寻求肿瘤诊断的生物标记物及治疗靶点。因此该文通过综述国内外最新的有关circRNA通过miRNA调控肿瘤的研究,为进一步探究circRNA调节各种癌症疾病的发生和发展的具体机制奠定基础,也为相关疾病的治疗和预防提供更加可靠的理论依据。
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| 关 键 词： | circRNA MIRNA 肿瘤 |
MiRNA-Mediated CircRNA Regulates the Development of Tumors |
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| Authors: | LI Yuexuan ZHANG Miao ZOU Jun |
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| Institution: | (School of Kinesiology,Shanghai University of Sport,Shanghai 200438,China) |
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| Abstract: | CircRNA(circular RNA)is a kind of ncRNA(non-coding RNA)with a special circular structure and has a variety of biological functions.With the deepening of research,circRNA was found to inhibit the expression of miRNA(micro RNA)through sponge adsorption,thus regulating the development of tumors in various systems.Furthermore,one circRNA can also involved in the regulation of the expression of one or more miRNAs.This finding is helpful to seek biomarkers for tumor diagnosis and therapeutic targets.Therefore,this paper reviews the latest domestic and foreign studies on circRNA regulates tumors through miRNA,which lays a foundation for further study on exploring the mechanism of circRNA regulating the occurrence and development of various cancer diseases,as well as provides a reliable theoretical basis for the treatment and prevention of related diseases. |
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| Keywords: | circRNA miRNA tumors |
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