Effects of corticotropin releasing factor on locomotor activity in hypophysectomized rats |
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| Authors: | Maryruth Eaves Karen Thatcher-Britton Jean Rivier Wylie Vale George F. Koob |
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| Affiliation: | 1. Division of Preclinical Neuroscience and Endocrinology, Scripps Clinic and Research Foundation 10666 North Torrey Pines La Jolla, CA 92037 USA;2. Department of Psychiatry, San Diego Veterans Administration Medical Center and UCSD School of Medicine La Jolla, CA 92093 USA;3. The Clayton Foundation Laboratories for Peptide Biology, Salk Institute, P. O. Box 85800, San Diego, CA 92138 USA |
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| Abstract: | Corticotropin releasing factor (CRF) injected intracerebroventricularly to hypophysectomized and sham hypophysectomized rats produced a dose dependent increase in locomotor activity, but in untreated hypophysectomized rats 10× more CRF was needed to produce a significant increase in activity. Concomitant daily supplements of rat growth hormone, thyroxine, and corticosterone to the hypophysectomized rats eliminated locomotor activity differences between the two groups. There was no statistically significant difference in locomotor response to either saline, 0.1 μg CRF, 1.0 μg CRF or 10.0 μg CRF in the group of animals receiving hormonal supplements. These results demonstrate that CRF can produce behavioral activation in rats independently of its effects on releasing hormones from the pituitary gland. |
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| Keywords: | Corticotropin releasing factor Hypophysectomy Locomotion Growth hormone pituitary |
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