Initiation of DNA replication in higher eukaryotes |
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Authors: | Razin S V |
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Institution: | Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334 Russia. sergey.v.razin@usa.net |
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Abstract: | In this review, of problems concerning initiation of DNA replication in higher eukaryotes is discussed, with special emphasis on the methods of replication origin mapping and biological tests for the activity of DNA replication origins in higher eukaryotes. Protein factors interacting with replication origins are considered in detail. The main events of replication initiation in higher eukaryotes are briefly analyzed. New data on the control of replication timing of large genomic regions are discussed. |
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