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双歧啤酒对延缓衰老作用的研究
引用本文:穆小萍,张德纯,邱建. 双歧啤酒对延缓衰老作用的研究[J]. 中国微生态学杂志, 2008, 20(4): 343-344
作者姓名:穆小萍  张德纯  邱建
作者单位:重庆医科大学,临床检验诊断学省部共建教育部重点实验室,病原生物学教研室,重庆,400016
基金项目:重庆医科大学校科研和教改项目
摘    要:目的研究双歧啤酒的延缓衰老作用。方法将老龄小鼠和黑腹果蝇随机分成纯净水对照组、市售啤酒对照组和双歧啤酒低、中、高三个剂量组,进行果蝇生存实验,检测小鼠血液中超氧化物歧化酶(SOD)、谷光甘肽过氧化物酶(GSH-PX)的活性和丙二醛(MDA)的含量。结果与对照组比较,双歧啤酒高、中剂量组能显著延长果蝇的半数死亡时间、平均寿命和平均最高寿命,提高老龄小鼠血液中SOD、GSH-PX的活性,降低老龄小鼠血液中MDA的含量。结论双歧啤酒具有延缓衰老的作用。

关 键 词:双歧啤酒  延缓衰老  老龄小鼠  黑腹果蝇

A study on anti-aging effect of brewing bifidobeer in mice and drosophila melanogasters
MU Xiao-ping,ZHANG De-chun,QIU Jian. A study on anti-aging effect of brewing bifidobeer in mice and drosophila melanogasters[J]. Chinese Journal of Microecology, 2008, 20(4): 343-344
Authors:MU Xiao-ping  ZHANG De-chun  QIU Jian
Affiliation:( Key Laboratory of Laboratory Medical Diagnostics,Ministry of Education ; Teaching-Research Section of Pathogenic Biology, Chongqing Medical University, Chongqing 400016, China)
Abstract:Objective To study the anti-aging effect of brewing bifidobeer in aged mice and drosophila melanogasters. Methods Aged mice and drosophila melanogasters were randomly assigned to 5 groups : the purified water control group,the ordinary beer control group and three brewing bifidobeer group. Survival experiments were conducted with dro- sophila melanogasters and the activity of superoxide dismutase(SOD) and glutathione peroxidase( GSH-PX), the content of malondialdehyde(MDA) in the blood of mice were measured. Results The median time ( LT50 ) , average life-span and maximal life-span of drosophila melanogasters and the activity of SOD and GSH-PX in the blood of aged mice in high and medium doses brewing bifidobeer groups increased significantly compared with control groups, while the content of MDA in the blood of aged mice in high and medium doses brewing bifidobeer groups decreased significantly compared with control groups. Conclusion Brewing bifidodeer has anti-aging effect on mice and drosophilae.
Keywords:Brewing bifidobeer  Anti-aging  Aged mice  Drosophila melanogasters
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