Essential trace elements in humans |
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Authors: | Daniel R Mayer Walter Kosmus Helmut Pogglitsch David mayer Wolfgang Beyer |
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Institution: | 1. Institute for Analytical Chemistry, Karl-Franzens-University Graz, Universit?tsplatz 1, 8010, Graz, Austria 2. Department of Nephrology, Karl-Franzens-University Graz, Medical Center, Auenbruggerplatz 11, 8036, Graz, Austria 3. Merkur Sanatorium, Eckerstra?e 98, 8020, Graz, Austria 4. Institute for Medical Chemistry and Pregl Laboratory, Karl-Franzens-University Graz, Harrachgasse 21, 8010, Graz, Austria
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Abstract: | Serum arsenic concentrations of persons suffering from renal failure and undergoing hemodialysis treatment (n=85) and of healthy controls (n=25) were determined by hydride-generation AAS technique after microwave digestion. The results were evaluated by comparing
the values of both groups, considering physiological factors and individual data, as well as comorbid conditions of the hemodialysis
(HD) patients. Serum arsenic levels were diminished in the patient group compared with controls (mean values 8.5±1.8 ng/mL
vs 10.6±1.3 ng/mL). Furthermore, additional diseases within the hemodialysis group, particularly injuries of the central nervous
system (CNS), vascular diseases, and cancer, were correlated to occasionally markedly decreased serum arsenic concentrations.
It was concluded that arsenic homeostasis is disturbed by HD treatment and certain additional diseases. Desirable arsenic
concentrations in the body seem to be reasonable. This consideration results in the conclusion that arsenic could play an
essential role in human health. Thus, reference arsenic concentrations in different human tissues and body fluids should be
established in order to recognize not only arsenic intoxication, but also arsenic deficiency. Perhaps arsenic deficiency contributes
to the increased death risk of HD patients, and therefore, arsenic supplementations for patients with extremely low serum
arsenic concentrations should be taken into account. |
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Keywords: | Arsenic hemodialysis serum microwave digestion hydride-generation atomic absorption spectrometry essential trace elements |
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