Effect of vanadate on cardiac contraction and adenylate cyclase. |
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| Authors: | G Grupp I Grupp C L Johnson E T Wallick A Schwartz |
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| Institution: | 1. Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine Cincinnati, Ohio 45267 USA;2. Department of Physiology, University of Cincinnati College of Medicine Cincinnati, Ohio 45267 USA;3. Department of Internal Medicine, Division of Cardiology University of Cincinnati College of Medicine Cincinnati, Ohio 45267 USA |
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| Abstract: | Vanadate produces a positive inotropic effect on ventricular muscle from rat, rabbit, guinea pig and cat; a positive inotropic effect on the atria of rat and rabbit, but a negative inotropic effect on the atria of guinea pig and cat. The effects of vanadate are completely reversible and occur in a concentration range of 10?5M to 10?3M. In this same concentration range, vanadate also causes a marked activation of cardiac adenylate cyclase suggesting that the positive inotropic action might be due in part to an elevation of cyclic AMP levels. The effects of vanadate are not influenced by alprenolol, cimetidine, or mepyramine, indicating a lack of involvement of β-adrenergic or histamine H2 and H1 receptors. |
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