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The effect of complexes of precursors and modulators of coenzyme Q biosynthesis on the functional state of heart mitochondria of old rats |
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| Authors: | E B Kuchmenko D N Petukhov G V Donchenko L S Mkhitaryan S V Tymoshchuk N A Strutynskaya G L Vavilova V F Sagach |
| Institution: | 1. Palladin Institute of Biochemistry of National Academy of Science of Ukraine, ul. Leontovicha 9, Kyiv, 01601, Ukraine 2. National Scientific Center “Strazhesko Institute of Cardiology”, Academy of Medical Sciences of Ukraine, ul. Narodnogo Opolcheniya 5, Kyiv, 03151, Ukraine 3. Bogomoletz Insitute of Physiology of National Academy of Sciences of Ukraine, ul. Bogomol’tza 4, Kyiv, 01024, Ukraine |
| Abstract: | Aging is accompanied by changes in activity of electron-transport enzyme complexes in myocardial mitochondria of old rats and by increased sensitivity of the mitochondrial permeability transition pore (MPTP) to inductors of its opening (Ca2+ and phenylarsine oxide). We also observed activation of lipid and protein free-radical peroxidation processes. Administration of a complex of biologically active substances that included precursors and modulators of coenzyme Q biosynthesis (α-tocopherol acetate, 4-hydroxybenzoic acid, and methionine) caused the increase in coenzyme Q content, correction of functional activity of mitochondrial electron-transport chain enzyme complexes, the decrease in intensity of lipid and protein free-radical peroxidation in the heart mitochondria and the decrease in sensitivity of mitochondrial permeability transition pore to inductors of its opening. This complex may be recommended for treatment of mitochondrial dysfunction in various pathologies of cardiovascular system, including in aging. |
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