Geographic distribution of methyltransferases of Helicobacter pylori: evidence of human host population isolation and migration |
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| Authors: | Filipa F Vale Francis Mégraud and Jorge MB Vítor |
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| Institution: | (1) Engineering Faculty, Portuguese Catholic University, Estrada Oct?vio Pato, 2635-631 Rio de Mouro, Portugal;(2) INSERM U853, F 33076 Bordeaux, France;(3) iMed.UL (MedChem Division), Faculty of Pharmacy, University of Lisbon, Av. das For?as Armadas, 1649-003 Lisboa, Portugal |
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| Abstract: | Background
Helicobacter pylori colonizes the human stomach and is associated with gastritis, peptic ulcer, and gastric cancer. This ubiquitous association
between H. pylori and humans is thought to be present since the origin of modern humans. The H. pylori genome encodes for an exceptional number of restriction and modifications (R-M) systems. To evaluate if R-M systems are an
adequate tool to determine the geographic distribution of H. pylori strains, we typed 221 strains from Africa, America, Asia, and Europe, and evaluated the expression of different 29 methyltransferases. |
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