Structure of a full-length cDNA clone for the prepro alpha 1(I) chain of human type I procollagen. |
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| Authors: | G Tromp H Kuivaniemi A Stacey H Shikata C T Baldwin R Jaenisch and D J Prockop |
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| Institution: | Department of Biochemistry and Molecular Biology, Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Jefferson Medical College, Philadelphia, PA 19107. |
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| Abstract: | A full-length cDNA clone for the human prepro alpha 1(I) chain of type I procollagen was characterized. Nucleotide sequencing of the first 1500 nucleotide residues of the 5'-end of the cDNA clone provided 729 nucleotide residues and the codons for 243 amino acid residues not previously defined from any species. The data made it possible, for the first time, to compare completely codon usage for the human alpha 1(I) and alpha 2(I) chains. |
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