A correlation between shortened life span and UV-sensitivity in some strains of Saccharomyces cerevisiae.

Summary From a UV-irradiated sample of diploid cells several clones were isolated, which produced cells with a shortened life span. A closer examination of three of these clones showed among other deviations from the wild type a higher sensitivity to UV-irradiation. Three other clones, which were selected from a haploid strain as UV-sensitive mutants, proved to be shortlived as well. In all these strains photoreactivation and liquid holding reactivation were unimpaired. There was no cross-sensitivity to X-irradiation. The correlation between shortened life span and UV-sensitivity is discussed.These studies were aided in part by a grant of the Deutsche Forschungsgemeinschaft.