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Profiling of a suramin-derived compound library at recombinant human P2Y receptors identifies NF272 as a competitive but non-selective P2Y2 receptor antagonist
Authors:Brockmann  Nicole  Sureechatchaiyan  Parichat  Müller  David  Hennicke  Tatiana  Hausmann  Ralf  Fritz  Gerhard  Hamacher  Alexandra  Kassack  Matthias U
Institution:1.Institute of Pharmaceutical and Medicinal Chemistry, Pharmaceutical Biochemistry, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany
;2.Institute of Toxicology, Heinrich-Heine-University of Duesseldorf, Duesseldorf, Germany
;3.Molecular Pharmacology, Rheinisch-Westfaelische Technische Hochschule Aachen, RWTH Aachen University, Aachen, Germany
;
Abstract:Purinergic Signalling - Extracellular nucleotides mediate multiple physiological effects such as proliferation, differentiation, or induction of apoptosis through G protein–coupled P2Y...
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