UV Filters,Ingredients with a Recognized Anti-Inflammatory Effect |
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| Authors: | Céline Couteau Catherine Chauvet Eva Paparis Laurence Coiffard |
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| Institution: | 1. Université de Nantes, Nantes Atlantique Universités, MMS, EA 2160, FR CNRS 3473 - Faculty of Pharmacy, Nantes, France.; 2. Université de Nantes, Nantes Atlantique Universités, Pharmacochemistry Department, Faculty of Pharmacy, Nantes University, Nantes Atlantique Universities, IICiMed UPRES EA 1155, Nantes, France.; CNRS-University of Toulouse, France, |
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| Abstract: | BackgroundTo explain observed differences during SPF determination using either an in vivo or in vitro method, we hypothesized on the presence of ingredients having anti-inflammatory properties.Methodology/Principal FindingsTo research our hypothesis, we studied the 21 UV filters both available on the market and authorized by European regulations and subjected these filters to the phorbol-myristate-acetate test using mice. We then catalogued the 13 filters demonstrating a significant anti-inflammatory effect with edema inhibition percentages of more than 70%. The filters are: diethylhexyl butamido triazone (92%), benzophenone-5 and titanium dioxide (90%), benzophenone-3 (83%), octocrylène and isoamyl p-methoxycinnamate (82%), PEG-25 PABA and homosalate (80%), octyl triazone and phenylbenzimidazole sulfonic acid (78%), octyl dimethyl PABA (75%), bis-ethylhexyloxyphenol methoxyphenyl triazine and diethylamino hydroxybenzoyl hexylbenzoate (70%). These filters were tested at various concentrations, including their maximum authorized dose. We detected a dose-response relationship.Conclusions/SignificanceThe anti-inflammatory effect of a sunscreen ingredient may affect the in vivo SPF value. |
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