Double-stranded nucleic acids in liquid-crystalline dispersions as building blocks for cross-linked supramolecular structures |
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| Authors: | Yevdokimov Y M Salyanov V I Mchedlischvili B V Bykov V A Belyaev A V Saunin S A Spener F Palumbo M |
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| Affiliation: | VA Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, Moscow. |
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| Abstract: | Double-stranded DNA fixed in a cholesteric liquid-crystalline dispersion was used for generating an ordered supramolecular structure in the presence of anthracycline and copper (II) ions. The structure is stable in a water-salt solution and does not require poly(ethyleneglycol).The ordered network can be immobilized on the surface of a polymeric film, and may collapse in the presence of biologically and pharmacologically relevant compounds. Accordingly, the DNA-based liquid-crystalline network represents the basis to obtain novel highly sensitive biosensing units. |
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