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Integrated gene networks in breast cancer development |
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| Authors: | Ivana Ratkaj Emil Stajduhar Srdan Vucinic Sime Spaventi Hrvojka Bosnjak Kresimir Pavelic Sandra Kraljevic Pavelic |
| Affiliation: | (1) Department of Biotechnology, University of Rijeka, Trg brace Mazuranica 10, 51000 Rijeka, Croatia;(2) Department of Radiology, Clinical hospital “Sisters of mercy”, Vinogradska cesta 29, 10000 Zagreb, Croatia;(3) Laboratory for Systems Biomedicine, Division of Molecular Medicine, Ruder Boskovic Institute, Bijenicka cesta 54, 10000 Zagreb, Croatia;(4) Croatian Academy of Sciences and Arts, Zrinski trg 11, 10000 Zagreb, Croatia;(5) Department of Internal Medicine, Clinical hospital “Sisters of mercy”, Vinogradska cesta 29, 10000 Zagreb, Croatia |
| Abstract: | Breast cancer is a complex and heterogenous disease. Classical molecular medical approaches cannot fully understand and comprehend its pathogenesis. In this review, the development of new biological markers for the early detection and creation of guided and specific therapy of breast cancer are discussed in light of the rapid advances in the “omics”. Results of cancer research in combination with large-scale methods that examine the expression status of genes and proteins have identified a large number of new biomarkers as well as confirmed the human growth hormone as an important player in the pathogenesis of this disease through its autocrine regulation where it influences the activation of Pax5 and HOXA1 gene networks. |
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