Regional mapping of liver type 6 phosphofructokinase isoenzyme on chromosome 21 |
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| Authors: | B Chadefaux M O Rethoré D Allard |
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| Institution: | (1) Laboratoire de Biochimie Génétique, Hôpital Necker-Enfants Malades, 149 rue de Sèvres, F-75743 Paris Cedex 15, France;(2) Institut de Progénèse, 45 rue des Saints Pères, F-75270 Paris Cedex 06, France |
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| Abstract: | Summary Among several cases of partial monosomies and full and partial trisomies 21, the enzymatic activity of phosphofructokinase (PFK) is increased only in 21q21 21pter trisomy with a (T21/N) ratio equal to 1.35 and decreased in monosomy 21q2121pter. These results suggest that the human gene for liver-type PFK is located between 21q21 and 21pter. |
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