Role of phosphopantetheinyl transferase genes in antibiotic production by Streptomyces coelicolor |
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| Authors: | Lu Ya-Wen San Roman Adrianna K Gehring Amy M |
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| Affiliation: | Department of Chemistry, Williams College, 47 Lab Campus Dr., Williamstown, MA 01267, USA. |
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| Abstract: | ![]()
The phosphopantetheinyl transferase genes SCO5883 (redU) and SCO6673 were disrupted in Streptomyces coelicolor. The redU mutants did not synthesize undecylprodigiosin, while SCO6673 mutants failed to produce calcium-dependent antibiotic. Neither gene was essential for actinorhodin production or morphological development in S. coelicolor, although their mutation could influence these processes. |
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