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Synthesis of aminoquinazoline derivatives and their antiproliferative activities against melanoma cell line |
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| Authors: | Junsang Lee Bong Soo Nam Hwan Kim Chang-Hyun Oh So Ha Lee Seung Joo Cho Tae Bo Sim Jung-Mi Hah Dong Jin Kim Jinsung Tae Kyung Ho Yoo |
| Affiliation: | 1. Life/Health Division, Korea Institute of Science and Technology, PO Box 131, Cheongryang, Seoul 130-650, Republic of Korea;2. Department of Chemistry, Yonsei University, Seodaemun-gu, Seoul 120-749, Republic of Korea;3. Research Center for Resistant Cells, Chosun University, Gwangju 501-759, Republic of Korea;4. Department of Cellular and Molecular Medicine, College of Medicine, Chosun University, 375 Seosuk-dong, Dong-gu Gwangju 501-759, Republic of Korea |
| Abstract: | The synthesis of a novel series of aminoquinazoline derivatives 1a–r and their antiproliferative activities against A375 human melanoma cell line were described. Among them, six compounds showed superior antiproliferative activities to Sorafenib as a reference compound. In particular, the representative compound 1q bearing chromen-4-one moiety exhibited excellent antiproliferative activity (IC50 = 0.006 μM) and good selectivity over HS27 fibroblast cell line. |
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