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Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases |
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| Authors: | Igor Beseda Laszlo Czollner Priti S Shah Rupesh Khunt Rawindra Gaware Paul Kosma Christian Stanetty Maria Carmen del Ruiz-Ruiz Hassan Amer Kurt Mereiter Thierry Da Cunha Alex Odermatt Dirk Claßen-Houben Ulrich Jordis |
| Institution: | 1. Inst. Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9, Vienna 1060, Austria;2. Saurashtra University, University Campus, Rajkot 360 005, India;3. Department of Chemistry, Univeristy of Natural Resources and Life Sciences, Muthgasse 18, Vienna 1190, Austria;4. Institute of Chemical Technologies and Analytics, University of Technology, Getreidemarkt 9, Vienna 1060, Austria;5. Division of Molecular and Systems Toxicology, Pharmacenter, University of Basel, Klingenbergstrasse 50, Basel 4056, Switzerland;6. Onepharm Research and Development, Veterinärplatz 1, Vienna 1210, Austria |
| Abstract: | The effect of glycyrrhetinic acid (GA) and GA-derivatives towards 11β-hydroxysteroid dehydrogenase (11β-HSD) was investigated. Novel compounds with modifications at positions C-3, C-11 and C-29 of the GA skeleton were prepared. Single crystal X-ray diffraction data of selected substances are reported and discussed. |
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