Antiproliferative activity of novel benzo[b][1,6]naphthyridines in human solid tumor cell lines |
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Authors: | Simonas Rudys Carla Ríos-Luci Eduardo Pérez-Roth Inga Cikotiene José M Padrón |
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Institution: | 1. Department of Organic Chemistry, Faculty of Chemistry, Vilnius University, Naugarduko 24, Vilnius LT-03225, Lithuania;2. BioLab, Instituto Universitario de Bio-Orgánica ‘Antonio González’ (IUBO-AG), Universidad de La Laguna, C/Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain;3. Instituto Canario de Investigación del Cáncer (ICIC), C/Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain |
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Abstract: | A series of 2-substituted 1,2-dihydro-3-phenyl-1-(trichloromethyl)benzob]1,6]naphthyridines were synthesized and their in vitro antiproliferative activities were examined against human solid tumor cell lines and relevant strains of bacteria and Candida. The compounds induced considerably growth inhibition in all cancer cell lines, whilst showed inactive against microbial strains. Furthermore, we found analog 2-ethoxy-1H-pyrano4,3-b]quinoline as selective inhibitor of microbial strains. |
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