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Synthesis and evaluation of amides surrogates of dopamine D3 receptor ligands |
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| Authors: | Mickaël Jean Jacques Renault Nicolas Levoin Denis Danvy Thierry Calmels Isabelle Berrebi-Bertrand Philippe Robert J.C. Schwartz J.M. Lecomte Philippe Uriac Marc Capet |
| Affiliation: | 1. UPRES EA 4090, Substances Lichéniques et Photoprotection, Université de Rennes I, Faculté des Sciences Biologiques et Médicales, 2, Av. du Pr. Léon Bernard, 35043 Rennes, France;2. Bioprojet-Biotech, 4 rue du Chesnay Beauregard, BP 96205, 35762 Saint-Grégoire, France |
| Abstract: | Isosteric replacement of the amide function and modulation of the arylpiperazine moiety of known dopamine D3 receptor ligands led to potent and selective compounds. Enhanced bioavailability and preferential brain distribution make compound 6c a good candidate for pharmacological and clinical evaluation. |
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