|
|||||
|
|
Discovery of novel sphingosine kinase-1 inhibitors. Part 2 |
|
| Authors: | Yibin Xiang Bradford Hirth John L Kane Junkai Liao Kevin D Noson Christopher Yee Gary Asmussen Maria Fitzgerald Christine Klaus Michael Booker |
| Institution: | 1. Department of Medicinal Chemistry, Drug and Biomaterial R&D, Genzyme Corporation, 153 Second Avenue, Waltham, MA 02451, USA;2. Department of In Vitro Biology, Drug and Biomaterial R&D, Genzyme Corporation, 153 Second Avenue, Waltham, MA 02451, USA;3. Department of DMPK, Drug and Biomaterial R&D, Genzyme Corporation, 153 Second Avenue, Waltham, MA 02451, USA |
| Abstract: | Building on our initial work, we have identified additional novel inhibitors of sphingosine kinase-1 (SK1). These new analogs address the shortcomings found in our previously reported compounds. Inhibitors 51 and 54 demonstrated oral bioavailability in a rat PK study. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |