C2-Symmetric azobenzene-amino acid conjugates and their inhibition of Subtilisin Kexin Isozyme-1 |
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| Authors: | Amit Basak Debarati Mitra Amit K Das Dayani Mohottalage Ajoy Basak |
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| Institution: | 1. Department of Chemistry, Indian Institute of Technology, Kharagpur 721 302, India;2. Department of Biotechnology, Indian Institute of Technology, Kharagpur 721 302, India;3. Chronic Disease Program, Regional Protein Chemistry Center, Ottawa Hospital Research Institute, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Canada |
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| Abstract: | C2-Symmetric azobenzene-amino acid/peptide hybrids containing stable E-azo moiety have been synthesized. Upon irradiation with long wavelength UV, these compounds isomerized to the Z-form, whose thermal reisomerization to the E isomer slowed down considerably. These compounds exhibited in vitro moderate to strong inhibition of mammalian cellular protease Subtilisin Kexin Isozyme-1, also called Site 1 Protease, which plays vital roles in cholesterol synthesis, lipid metabolism, bone formation, and viral infections. |
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