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Asymmetric syntheses of daedalin A and quercinol and their tyrosinase inhibitory activity
Authors:Mitsuo Sekimoto  Yasunao Hattori  Keiji Morimura  Mitsuru Hirota  Hidefumi Makabe
Institution:1. Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University, 8304, Minami-minowa, Kami-ina, Nagano 399-4598, Japan;2. Department of Chemistry, Graduate School of Medicinal Science, Kyoto Prefectural University of Medicine, Kita-ku, Kyoto 603-8334, Japan;3. Geol Cosmetics. Co., Ltd, 111-1, Shinmura, Katsuragi, Nara 639-2121, Japan;4. Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University, 8304, Minami-minowa, Kami-ina, Nagano 399-4598, Japan
Abstract:Stereoselective syntheses of daedalin A and quercinol, an enantiomer of daedalin A, is described. The tyrosinase inhibitory activities of daedalin A and quercinol were examined. The activity of quercinol was weaker than that of daedalin A at high concentration.
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