|
|||||
|
|
Inhibitors of osteoclastogenesis from Lawsonia inermis leaves |
|
| Authors: | Nguyen Xuan Cuong Nguyen Xuan Nhiem Nguyen Phuong Thao Nguyen Hoai Nam Nguyen Tien Dat Hoang Le Tuan Anh Le Mai Huong Phan Van Kiem Chau Van Minh Ji-Hee Won Won-Yoon Chung Young Ho Kim |
| Affiliation: | 1. Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi, Viet Nam;2. College of Pharmacy, Chungnam National University, Daejeon 305 764, Republic of Korea;3. Department of Oral Biology, Yonsei University College of Dentistry, Seoul 120 752, Republic of Korea |
| Abstract: | Ten phenolic compounds (1–10) were isolated from a methanol extract of Lawsonia inermis leaves including two new ones, lawsoniasides A (1) and B (2). Their structures were elucidated by spectroscopic methods (NMR and FTICRMS) in combination with acid hydrolysis and GC analyses. Compounds 4 and 5 showed a significant inhibition on receptor activator for nuclear factor-κB ligand-induced osteoclast formation in murine bone-marrow macrophages. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |