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The P2X7 receptor antagonist JNJ-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in SOD1G93A mice |
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| Authors: | Ly Diane Dongol Anjila Cuthbertson Peter Guy Thomas V Geraghty Nicholas J Sophocleous Reece A Sin Lucia Turner Bradley J Watson Debbie Yerbury Justin J Sluyter Ronald |
| Institution: | 1.Illawarra Health and Medical Research Institute, Wollongong, NSW, 2522, Australia ;2.Molecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, NSW, 2522, Australia ;3.Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, 3052, Australia ; |
| Abstract: | Purinergic Signalling - The ATP-gated P2X7 ion channel has emerging roles in amyotrophic lateral sclerosis (ALS) progression. Pharmacological blockade of P2X7 with Brilliant Blue G can ameliorate... |
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