首页 | 本学科首页   官方微博 | 高级检索  
     


Solid phase synthesis of 2-aminobenzothiazoles
Authors:Francesco Piscitelli  Carlo Ballatore  Amos B. Smith
Affiliation:1. Department of Chemistry, University of Pennsylvania, 231 South 34th St., Philadelphia, PA 19104-6323, United States;2. Department of Pathology & Laboratory Medicine, University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104-6323, United States
Abstract:A traceless solid supported protocol for the synthesis of 2-aminobenzothiazoles is described, employing resin-bound acyl-isothiocyanate and a series of anilines. Cyclization of the resulting N-acyl, N′-phenyl-thioureas generates the 2-aminobenzothiazole scaffold, which can be further elaborated prior to hydrazine-mediated cleavage of the final products from the carboxy-polystyrene resin. A small, focused library of 2-aminobenzothiazoles was prepared.
Keywords:
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号