Solid phase synthesis of 2-aminobenzothiazoles |
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| Authors: | Francesco Piscitelli Carlo Ballatore Amos B. Smith |
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| Affiliation: | 1. Department of Chemistry, University of Pennsylvania, 231 South 34th St., Philadelphia, PA 19104-6323, United States;2. Department of Pathology & Laboratory Medicine, University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104-6323, United States |
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| Abstract: | A traceless solid supported protocol for the synthesis of 2-aminobenzothiazoles is described, employing resin-bound acyl-isothiocyanate and a series of anilines. Cyclization of the resulting N-acyl, N′-phenyl-thioureas generates the 2-aminobenzothiazole scaffold, which can be further elaborated prior to hydrazine-mediated cleavage of the final products from the carboxy-polystyrene resin. A small, focused library of 2-aminobenzothiazoles was prepared. |
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