Synthesis,in vitro and in vivo studies of Gd-DTPA-XDA-D1-Glc(OH) complex as a new potential MRI contrast agent |
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| Authors: | Nobuhisa Ozaki Arigala Uma Ravi Sankar Mitsuji Yamashita Takashi Aoki Yasutaka Tanaka Motohiko Kimura Mitsuo Toda Michio Fujie Yasuo Takehara Harumi Sakahara |
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| Institution: | 1. Graduate School of Science and Technology, Shizuoka University, Hamamatsu 432-8561, Japan;2. Japan Association for the Advancement of Medical Equipment (JAAME), Hongo, Bunkyo-ku, Tokyo 113-0033, Japan;3. Department of Materials Science and Chemical Engineering, Faculty of Engineering, Shizuoka University, Hamamatsu 432-8561, Japan;4. Department of Radiology, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan |
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| Abstract: | A new type of dendritic molecules Gd-DTPA-XDA-D1-Glc(OH), which work as a functionalized ligand coordinating gadolinium(III) ion at the center of their frameworks with two glucose moieties on the molecular surfaces, were readily synthesized with high yield. The structures were established by IR, 1H, 13C NMR, and mass spectral studies. Its bio-distribution patterns were evaluated on rats. |
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