Design of riboflavin-presenting PAMAM dendrimers as a new nanoplatform for cancer-targeted delivery |
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| Authors: | Thommey P Thomas Seok Ki Choi Ming-Hsin Li Alina Kotlyar James R Baker |
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| Institution: | Michigan Nanotechnology Institute for Medicine and Biological Sciences, Department of Internal Medicine, Division of Allergy, University of Michigan, 9220 MSRB III, Box 0648, Ann Arbor, MI 48109, USA |
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| Abstract: | This communication describes the synthesis and in vitro biological evaluation of novel generation 5 PAMAM dendrimers conjugated with riboflavin as a targeting ligand. Cell-based experiments demonstrated that a dendrimer conjugated with riboflavin is able to undergo cellular binding and uptake in KB cells, and when the dendrimer is also conjugated with methotrexate, the riboflavin dendrimer conjugate can potently inhibit cell growth. |
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