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Comparative biological evaluation of two ethylene linked mixed binuclear ferrocene/ruthenium organometallic species |
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| Authors: | Ingo Ott Konrad Kowalski Ronald Gust Jörg Maurer Philipp Mücke Rainer F. Winter |
| Affiliation: | 1. Institute of Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, Germany;2. Department of Organic Chemistry, Faculty of Chemistry, University of ?ód?, Tamka 12, 91-403 ?ód?, Poland;3. Institute of Pharmacy, Freie Universität Berlin, Königin-Luise-Str. 2+4, 14195 Berlin, Germany;4. Institut für Anorganische Chemie der Universität Regensburg, Universitätsstraße 31, D-93040 Regensburg, Germany |
| Abstract: | Two ethylene linked binuclear mixed ferrocene/ruthenium complexes were biologically investigated in comparison to structurally related mononuclear ferrocene or ruthenium species with styryl substituents or ligands. Results indicated that the electron distribution (but not the redox potential), cellular uptake and (to some minor extent) anti-estrogenic effects were the key contributors to antiproliferative effects observed in tumor cell lines. |
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