| 尼莫地平对急性脑缺血大鼠一氧化氮和自由基的影响 |
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| 引用本文： | 江停战,汪远金.尼莫地平对急性脑缺血大鼠一氧化氮和自由基的影响[J].生物学杂志,1999,16(4):22-23. |
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| 作者姓名： | 江停战 汪远金 |
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| 作者单位： | 安徽中医学院附属医院(江停战，王晓日)，安徽中医学院中西医结合系!合肥230031(汪远金) |
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| 摘 要： | 本文在大鼠双侧颈总动脉闭塞的不完全性脑缺血模型上，观察了尼莫地平在脑缺血中对一氧化氮（ Ｎ Ｏ） 和自由基的影响。发现尼莫地平显著降低脑缺血大鼠血清中乳酸脱氢酶（ Ｌ Ｄ Ｈ） 活性，丙二醛（ Ｍ Ｄ Ａ）含量，增加 Ｎ Ｏ 含量。结果提示：尼莫地平对脑缺血大鼠的保护作用可能与其抗脂质过氧化及增加 Ｎ Ｏ 有关。
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| 关 键 词： | 尼莫地平 脑缺血 脂质过氧化 自由基 一氧化氮 |
Effect of acute brain ischemia in rats with nimodpine on nitric oxide and tree radical |
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| JIANG Ting-zhao,WANG Xiao-yang.Effect of acute brain ischemia in rats with nimodpine on nitric oxide and tree radical[J].Journal of Biology,1999,16(4):22-23. |
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| Authors: | JIANG Ting-zhao WANG Xiao-yang |
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| Abstract: | For observing the effect of nimodipine on nitric oxide and free redical in brain ischemia the models of incomplete brain ischemia in rats by occlusion of bilateral common carotid arteries were built It's found that nimodipine decreased the serum activity of Lavtate dehydrogenase(LDH)and content of malondialdehyde(MDA),and increased content of nitric oxids (NO).The results suggested that the protective effects of nimodipine on brain ischemia in rats may be related to its antilipid peroxidation and increased No content. |
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| Keywords: | nimodipine brain ischemia lipid pexoidation free radical nitric oxide |
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