| 防御素构效关系研究进展 |
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| 引用本文： | 王少然,杨雅麟,张军,王建华.防御素构效关系研究进展[J].生物技术通报,2011(4). |
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| 作者姓名： | 王少然 杨雅麟 张军 王建华 |
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| 作者单位： | 中国农业科学院饲料研究所农业部饲料生物技术重点开放实验室,北京,100081 |
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| 基金项目： | 国家自然科学基金项目，北京市自然科学基金项目 |
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| 摘 要： | 防御素是第一大类内源性抗微生物肤,具有广泛的抗菌谱作用,是生物体先天防御系统的重要组成成分.综述了近年国际上对防御素的一级结构、二级结构、三级结构和四级结构及其构效关系研究的最新进展.
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| 关 键 词： | 防御素 分子结构 抗菌活性 构效关系 |
Advances on Structure-activity Relationships of Defensins |
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| Wang Shaoran,Yang Yalin,Zhang Jun,Wang Jianhua.Advances on Structure-activity Relationships of Defensins[J].Biotechnology Bulletin,2011(4). |
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| Authors: | Wang Shaoran Yang Yalin Zhang Jun Wang Jianhua |
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| Institution: | Wang Shaoran Yang Yalin Zhang Jun Wang Jianhua(Key Laboratory of Feed Biotechnology of MOA,Feed Research Institute,Chinese Academy of Agricultural Sciences,Beijing 100081) |
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| Abstract: | Defensins are endogenous antimicrobial polypeptides and have broad wide spectrum of antibacterial activity that play a crucial role in the innate immune system.The primary,secondary,tertiary and quarternary structure of denfensins,and their structure-activity relationships were reviewed. |
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| Keywords: | Defensin Molecular structure Antimicrobial activity Structure-activity relationships |
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