伊曲康唑联合外用药物治疗花斑糠疹临床研究

目的探讨伊曲康唑胶囊联合1%盐酸布替萘芬乳膏和2%酮康唑洗剂治疗花斑糠疹的疗效及不良反应。方法入选患者按单双日分为两组,两组均口服伊曲康唑0.2g,1次/d,连续7d,同时外用1%盐酸布替萘芬乳膏,1次/d,连续14d,对照组停药观察,试验组同时使用2%酮康唑洗剂洗浴,每周2次,连用3个月。分别于治疗前、治疗后1、3、6、12个月评价疗效。结果试验组114例患者3个月时痊愈率78.1%,6个月时痊愈率90.4%,对照组125例患者3个月时痊愈率72.8%,6个月时痊愈率75.2%,12个月后试验组复发率1.8%,对照组为18.4%。结论伊曲康唑胶囊短时口服联合外用布替萘芬和酮康唑洗剂洗浴疗效较好,安全性高,使用方便,可大大降低花斑糠疹的复发率。

Treatment of pityriasis versicolor with itraconazole in combination with butenafine cream and ketoconazole lotion:a clinical study

Objective To evaluate the efficacy and safety of itraconazole capsule in combination with 1% butenafine hydrochloride of cream and ketoconazole lotion in the treatment of pityriasis versicolor.Methods Patients in two groups were administered with itraconazole（0.2 g,once daily）for 7 days and butenafine cream（once daily）for 2 weeks.Baths with ketoconazole lotion（twice one week）was administered only to the test group for 3 months.Clinical efficacy was evaluated after 1,3,6,12 months.Results The cure rate of test group（114 patients）after 3 months and 6 months were 78.1% and 90.4% respectively,while 72.8% and 75.2% in the control group（125 patients）.The relapse rate of test group and control group were 1.8% and 18.4% respectively.Conclusions Itraconazole in combination with butenafine cream and ketoconazole lotion is effective in the treatment of pityriasis versicolor and reducing the long-term relapse rate without obvious adverse effects.