肌肉脂肪酸转运膜蛋白及其相互关系

肌肉（骨骼肌）组织对脂肪酸的利用水平是影响机体能量稳态的关键因素.肌肉摄取的长链脂肪酸(long chain fatty acids，LCFAs)主要依赖细胞膜载体蛋白协助的跨膜转运过程.近年来，一系列与脂肪酸转运相关的膜蛋白被相继克隆鉴定，其中在肌肉中大量表达的有脂肪酸转运蛋白-1（fatty acid transport protein-1，FATP-1）、膜脂肪酸结合蛋白（plasma membrane fatty acid binding protein，FABPpm）、脂肪酸转位酶（fatty acid translocase，FAT/CD36）和小窝蛋白-1（caveolin-1）.研究上述肌肉脂肪酸转运膜蛋白的结构功能、调控机制及相互关系，可能为肥胖等脂类代谢紊乱疾病的诊治提供新的手段.

Membrane Fatty Acid Transporters in Muscles and their Relationships

The utilization of fatty acids in skeletal muscle plays an important role in the energy homeostasis of human body. The uptake of long-chain fatty acids in skeletal muscle mainly depends on their transmembrane-movement mediated by membrane transporters. In recently years, a series of membrane fatty acid transport proteins have been cloned and defined, and fatty acid transport protein-1(FATP-1), plasma membrane fatty acid binding protein(FABPpm), fatty acid translocase (FAT/CD36)and caveolin-1 were found to widely expressed in skeletal muscle, thus it may provide a new way of diagnosis and treating for lipid metabolism disorder diseases, such as obesity，by investigation on the structure, function ,regulation mechanisms of these transporters and their relationship.