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| 2型糖尿病患者血清MCP-1与下肢大血管病变的相关性 | |
| 引用本文： | 冯罡,孙玥,王晓丽,徐上知,孙侃.2型糖尿病患者血清MCP-1与下肢大血管病变的相关性[J].现代生物医学进展,2010,10(2). |
| 作者姓名： | 冯罡 孙玥 王晓丽 徐上知 孙侃 |
| 作者单位： | 1. 石河子大学医学院,新疆,石河子,832008 2. 石河子大学医学院第一附属医院内分泌科,新疆,石河子,832008 3. 石河子大学医学院卫生学教研室,新疆,石河子,832008 |
| 基金项目： | 新疆生产建设兵团科技攻关计划(社会发展)项目基金资助(2007GG19) |
| 摘 要： | 目的:讨论2型糖尿病(T2DM)患者血清单核细胞趋化蛋白-1(monocyte chemoattractant protein-1;MCP-1)与下肢大血管病变的相关性。方法:(1)2型糖尿病患者61例,根据是否合并下肢大血管病变,分成无下肢大血管病变组(30例)、合并下肢大血管病变组(31例)与正常对照组(20例)对比,用双抗体夹心ELISA法测出血清MCP-1,比较组间血清MCP-1水平的异常。(2)测出各组甘油三酯、胆固醇、低密度脂蛋白、高密度脂蛋白、空腹血糖、糖化血红蛋白、纤维蛋白原等水平,分析各指标和2型糖尿病大血管病变的相关性。结果:(1)2型糖尿病组血清MCP-1水平明显高于正常对照组(P<0.05),合并下肢大血管病变组血清MCP-1水平明显高于无下肢大血管病变组和正常对照组(P<0.05),(2)以T2DM组为整体,有无下肢大血管病变为因变量Y(有=1,无=0),用MCP-1等其它危险因素为自变量,Logstic回归分析,病程、收缩压和MCP-1入回归方程。结论:MCP-1可能是T2DM下肢大血管病变的一个重要的独立危险因素。 |
| 关 键 词： | 2型糖尿病 单核细胞趋化蛋白-1 下肢大血管病变 |
Study on the Relationship Between MCP-1 and Lower Limb Macroangiopathy in Type 2 Diabetics |
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| FENG gang,SUN Yue,WANG Xiao-li,XU Shang-zhi,SUN Kan.Study on the Relationship Between MCP-1 and Lower Limb Macroangiopathy in Type 2 Diabetics[J].Progress in Modern Biomedicine,2010,10(2). | |
| Authors: | FENG gang SUN Yue WANG Xiao-li XU Shang-zhi SUN Kan |
| Institution: | FENG gang1,SUN Yue2,WANG Xiao-li2,XU Shang-zhi3,SUN Kan2(1 Grade 2007 Lic Med in medical college of Shi Hezi university,XinJiang ShiHezi,832000,China,2 Department of Endocrinology,the first affiliated hospital of medical college,Shi hezi university . XinJiang ShiHezi,3 the medical college of Shihezi university. XinJiang ShiHezi,China) |
| Abstract: | Objective:To assess the association of circulating levels of MCP-1 and type 2 diabetes mellitus with/without macroangiopathy of lower limb. Methods:(1) To measure the plasma levels of MCP-1 by ELISA in 61 type 2 diabetic patients with or without lower limb blood vessels and 20 normal controls. the difference between the three groups was compared. The serum concentra-tion of TG,TC,LDL,HDL-ch,FPG,HbA1c,FIB was determined in the three groups,in order to analyze their relationship with macroangiopathy of lower ... |
| Keywords: | Type 2 diabetes mellitus monocyte chemoattractant protein-1 Macroangiopathy of lower limb |
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