Experimental studies on ultralow frequency pulsed gradient magnetic field inducing apoptosis of cancer cell and inhibiting growth of cancer cell |
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Authors: | Fanqing Zeng Congyi Zheng Xinchen Zhang Zongshan Li Chaoyang Li Chuanying Wang Xinsong Zhang Xiaoling Huang and Husheng Zhang |
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Institution: | 1. College of Electronic Information, Wuhan University, Wuhan 430072, China;The Center of Instrumental Analysis, Wuhan University, Wuhan 430072, China 2. College of Life Science, Wuhan University, Wuhan 430072, China 3. College of Electronic Information, Wuhan University, Wuhan 430072, China 4. Medical College, Wuhan University, Wuhan 430071, China 5. Wuhan Institute of Rock and Soil Mechanics, Chinese Academy of Sciences, Wuhan 430071, China 6. The Business School, Wuhan University, Wuhan 430072, China 7. Biomedical Physics Unit, Department of Physics, Wuhan University, Wuhan 430072, China |
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Abstract: | The morphology characteristics of cell apoptosis of the malignant tumour cells in magnetic field-treated mouse was observed for the first time. The apoptotic cancer cell contracted, became rounder and divorced from adjacent cells; the heterochromatin condensed and coagulated together along the inner side of the nuclear membrane; the endoplasmic reticulums(ER) expanded and fused with the cellular membrane; many apoptotic bodies which were packed by the cellular membrane appeared and were devoured by some lymphocytes and plasma. Apoptosis of cancer cells was detected by terminal deoxynucleotidyl transferase mediated in situ nick end labeling(TUNEL). It was found that the number of apoptosis cancer cells of the sample treated by the magnetic field is more than that of the control sample. The growth of malignant tumour in mice was inhibited and the ability of immune cell to dissolve cancer cells was improved by ultralow frequency(ULF) pulsed gradient magnetic field; the nuclei DNA contents decreased, indicating that magnetic field can block DNA replication and inhibit mitosis of cancer cells. It was suggested that magnetic field could inhibit the metabolism of cancer cell, lower its malignancy, and restrain its rapid and heteromorphic growth. Since ULF pulsed gradient magnetic field can induce apoptosis of cancer cells and inhibit the growth of malignant tumour, it could be used as a new method to treat cancer. |
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Keywords: | ultralow frequency(ULF) pulsed gradient magnetic field cancer cell apoptosis inducing in situ nick end labeling division inhibiting |
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