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Glycosaminoglycans modulate C6 glioma cell adhesion to extracellular matrix components and alter cell proliferation and cell migration |
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| Authors: | Claudia?Beatriz?Nedel?Mendes de Aguiar Bruno?Lob?o-Soares Marcio?Alvarez-Silva |
| Institution: | 1.Departamento de Biologia Celular, Embriologia e Genética, Centro de Ciências Biológicas,Universidade Federal de Santa Catarina,Florianópolis,Brazil;2.Faculdade de Medicina de Ribeir?o Preto, Hospital das Clinicas de Ribeir?o Preto,Universidade de S?o Paulo,Ribeir?o Preto,Brazil |
| Abstract: | BackgroundAdhesion to extracellular matrix (ECM) components has been implicated in the proliferative and invasive properties of tumor cells. We investigated the ability of C6 glioma cells to attach to ECM components in vitro and described the regulatory role of glycosaminoglycans (GAGs) on their adhesion to the substrate, proliferation and migration. |
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