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Soluble CD40 ligand in haemodialysis patients: survival impact and cardiovascular prognostic role |
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| Authors: | Crina Rusu Simona Racasan Diana Moldovan Ina Maria Kacso Alina Potra Cosmina Ioana Bondor |
| Affiliation: | 1. Department of Nephrology, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania;2. Nefromed Dialysis Center, Cluj-Napoca, Romania;3. Department of Statistics, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania |
| Abstract: | Context: Soluble CD40 ligand (sCD40l) can predict cardiovascular events (CVE) and mortality in haemodialysis (HD) patients (short-, medium-term follow-up studies). Objective: To evaluate the relationship between sCD40l and survival, CVE and mortality in HD patients on long-term follow-up. Methods: We registered 46?HD patients’ baseline characteristics, mortality and CVE for 108 months. Results: SCD40l correlated positively with C-reactive protein, was higher in survivors, but had no impact on survival and was not predictive for CVE or CV mortality. Conclusion: The levels of sCD40l have no influence on survival or CVE and mortality in HD patients in a long-term follow-up. |
| Keywords: | Cardiovascular disease immunotoxicity renal disease |