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Plasma myostatin levels are related to the extent of right ventricular dysfunction in exacerbation of chronic obstructive pulmonary disease |
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| Authors: | Chun-Rong Ju Jian-Heng Zhang Miao Chen |
| Institution: | State Key Lab of the Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangdong, China |
| Abstract: | Objective: To investigate the relationship between plasma myostatin levels and right ventricle (RV) dysfunction (RVD) in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: The study recruited 84 patients with AECOPD. Plasma myostatin was analyzed and tricuspid annular plane systolic excursion (TAPSE)?<?16?mm was used as the main indicator for RVD. Results: Plasma myostatin levels were significantly higher in 47 patients with RVD than 37 ones without (P?<?0.005). Multivariate regression analysis revealed that myostatin levels correlated significantly with TAPSE values and RV myocardial performance index (p?<?0.001) among the study patients. Conclusion: Plasma myostatin is a potential biomarker for improving diagnosis of RVD in AECOPD. |
| Keywords: | Chronic obstructive pulmonary disease myostatin pulmonary arterial hypertension right ventricle tricuspid annular plane systolic excursion |