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Micronuclei as a marker for medical screening of subjects continuously occupationally exposed to low doses of ionizing radiation |
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| Authors: | Jelena Pajic Dubravka Jovicic Aleksandar PS Milovanovic |
| Institution: | 1. Serbian Institute of Occupational Health “Dr Dragomir Karajovic”, Belgrade, Serbia;2. Genotoxicology Department, Faculty of Applied Ecology “Futura”, University “Singidunum”, Belgrade, Serbia;3. Occupational Health Department, Faculty of Medicine, University of Belgrade, Belgrade, Serbia |
| Abstract: | Context: Genotoxicity assays are widely employed in human biomonitoring studies to assess genetic damage inflicted by genotoxic agents. Objective: Evaluation of micronuclei (MN) as a screening marker of occupational ionizing radiation (IR) exposure. Materials and methods: Using micronucleus test, peripheral blood lymphocytes (PBL) of 402 control and exposed subjects were screened for genetic damage. Results: The mean frequencies of micronucleus test parameters were significantly higher in exposed persons. Increase of micronucleus yield with duration of exposure (DOE) by 0.303MN/year was revealed. Discussion and conclusion: The obtained data encourage us to consider MN as valuable markers for preventive medical screening of occupationally exposed groups. |
| Keywords: | Micronuclei biomarkers low-dose ionizing radiation occupational exposure medical screening |