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Prognostic significance of insulin-like growth factor-I serum levels in acute decompensation of cirrhosis |
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| Authors: | Bruno da Silveira Colombo Marcelo Fernando Ronsoni Pedro Eduardo Soares e Silva Leonardo Fayad Letícia Muraro Wildner Maria Luiza Bazzo |
| Institution: | 1. Division of Gastroenterology, Federal University of Santa Catarina, Florianópolis, Brazil;2. Department of Clinical Analysis, Federal University of Santa Catarina, Florianópolis, Brazil |
| Abstract: | Context: IGF-I serum levels are suppressed in cirrhosis, but its prognostic significance is unknown. Objectives: To investigate the prognostic value of IGF-I in patients admitted for acute decompensation of cirrhosis. Materials and methods: Cohort study that included 103 patients. IGF-I was measured by enzyme-linked immunosorbent assay (ELISA). Results: Ninety-day mortality was 26.2% and it was independently associated with MELD, age and IGF-I. The Kaplan–Meier survival probability at 90 days was 94.3% in patients with IGF-I?≥13?ng/mL and 63.2% for patients with IGF-I?<13?ng/mL (p?=?.001). Discussion and conclusion: IGF-I levels are independently associated with mortality in acute decompensation of cirrhosis. |
| Keywords: | Liver cirrhosis IGF-I ascites portal hypertension |