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Release kinetics of high-sensitivity cardiac troponins I and T and troponin T upstream open reading frame peptide (TnTuORF) in clinically induced acute myocardial infarction |
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| Authors: | Christoph Liebetrau Luise Gaede J. Sebastian Wolter Julia Homann Alexander Meyer Oliver Dörr |
| Affiliation: | 1. Department of Cardiology, Kerckhoff Heart and Thorax Center, Bad Nauheim, Germany;2. DZHK (German Center for Cardiovascular Research), partner site RheinMain, Frankfurt am Main, Germany;3. Department of Cardiac Surgery, Kerckhoff Heart and Thorax Center, Bad Nauheim, Germany;4. Medical Clinic I, Cardiology and Angiology, University of Giessen, Giessen, Germany |
| Abstract: | Context: Troponin T upstream open reading frame peptide (TnTuORF) may be useful as a novel biomarker in acute cardiac syndromes. Objective: The study examined the early release kinetics of TnTuORF. Materials and methods: We analyzed the time course of the release of cardiac troponins I and T and TnTuORF in patients (n?=?31) with hypertrophic obstructive cardiomyopathy undergoing transcoronary ablation of septal hypertrophy (TASH). Results: Fifteen minutes after TASH, the levels of both troponins increased significantly (cTnT median: 18?ng/L versus 27?ng/L; cTnI median: 15?ng/L versus 25?ng/L). TnTuORF showed no variation. Discussion: We observed a significantly greater increase in cTnI compared with cTnT. Conclusion: Our results demonstrate that troponin assays allow early detection of myocardial injury, whereas TnTuORF levels remain unchanged in this setting. |
| Keywords: | Acute coronary syndrome HOCM TASH |