Circulating endothelium-enriched microRNA-126 as a potential biomarker for coronary artery disease in type 2 diabetes mellitus patients |
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| Authors: | Ghada Al-Kafaji Ghazi Al-Mahroos Haifa Abdulla Al-Muhtaresh Mohamed Abdalla Sabry Rima Abdul Razzak Abdel Halim Salem |
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| Institution: | 1. College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Kingdom of Bahrain;2. Diabetes and Endocrinology Clinic, Salmaniya Medical Complex, Manama, Kingdom of Bahrain |
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| Abstract: | Circulating microRNAs (miRNAs) have been shown as promising biomarkers for various diseases. We investigated the predictive potential of circulating endothelium-enriched miR-126 in type 2 diabetes patients (T2D) without chronic complications and T2D patients with coronary artery diseases (CAD). The expression levels of circulating miR-126, determined by quantitative real time PCR, were decrease in peripheral blood of T2D patients and T2D with CAD compared with healthy controls. MiR-126 strongly associated with T2D and CAD, negatively correlated with LDL in CAD patients and differentiated between T2D patients, T2D patients with CAD and healthy subjects. Circulating miR-126 may serve as a biomarker for predicting patients with T2D and diabetic CAD. |
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| Keywords: | Biomarker circulating miR-126 coronary artery disease microRNAs type 2 diabetes |
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