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Differential expression of circulating vascular cell adhesion molecule-1 in subjects with coronary artery disease and cardiac syndrome X without known diabetes mellitus |
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| Authors: | Kae-Woei Liang Wayne H-H Sheu Wen-Jane Lee Wen-Lieng Lee Chia-Po Fu Jun-Sing Wang |
| Affiliation: | 1. Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan;2. School of Medicine, National Yang Ming University, Taipei, Taiwan;3. Department of Medicine, China Medical University, Taichung, Taiwan;4. School of Medicine, National Yang Ming University, Taipei, Taiwan;5. Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan;6. Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan;7. School of Medicine, National Defense Medical Center, Taipei, Taiwan;8. Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan;9. Tung-Hai University, Taichung, Taiwan;10. Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan |
| Abstract: | Context: Inflammation is one of the mechanisms underlying cardiac syndrome X (CSX). Objectives: Few studies have compared the expression of inflammatory or adhesion molecules between coronary artery disease (CAD) versus CSX. Materials and methods: Ninety-two CSX and 145 CAD subjects without known diabetes mellitus underwent coronary angiogram for angina. Results: Vascular cell adhesion molecule (VCAM)-1 (median, 507 versus 431?ng/ml, p?=?0.001) was significantly higher in the CAD group. In the binary regression, VCAM-1 was a significant differential factor for CAD versus CSX. Discussion and conclusion: Adhesion molecules might be implicated in the differential expression of macro versus microvascular coronary disease. Trial registration number: NCT01198730 at https://clinicaltrials.gov |
| Keywords: | Coronary artery disease cardiac syndrome X inflammation intercellular adhesion molecule-1 vascular cell adhesion molecule-1 |