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Automated genome mining for natural products |
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| Authors: | Michael HT Li Peter MU Ung James Zajkowski Sylvie Garneau-Tsodikova and David H Sherman |
| Institution: | (1) Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA;(2) Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI, USA;(3) Departments of Chemistry, and Microbiology & Immunology, University of Michigan, Ann Arbor, MI, USA |
| Abstract: | BackgroundDiscovery of new medicinal agents from natural sources has largely been an adventitious process based on screening of plant and microbial extracts combined with bioassay-guided identification and natural product structure elucidation. Increasingly rapid and more cost-effective genome sequencing technologies coupled with advanced computational power have converged to transform this trend toward a more rational and predictive pursuit. |
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