Synthesis of Tricyclic Phenylpyrrole Lactams, New Models of Antitubulin Agents |
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| Authors: | Jean-Pierre Alazard Corine Millet-Paillusson O Boy Daniel Gu nard Ang le Chiaroni Claude Riche and Claude Thal |
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| Institution: | Institut de Chimie des Substances Naturelles du C.N.R.S., 91198 Gif-sur-Yvette, France |
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| Abstract: | The tricyclic lactams 3 and 4 having a phenylpyrrole framework have been prepared from the arylpyrroles 5 and 16 respectively. These structural analogs of rhazinilam 1 present, like the latter, an interesting antitubulin and cytotoxic activity. |
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